Sponges are marine invertebrates that possess more than 20 categories of bioactive compounds, including antibiotics, antivirals, anti-inflammatories, anticancer, antileukemic, insecticidal, antihelminthic, and cytotoxins, making them attractive for development. Nutritionally, sponges are more suitable as microbial niches than nutrient-poor seawater. The interaction between bacteria and sponges is called mutualistic symbiosis, producing bioactive compounds. Sponges with high microbial abundance are called High-Microbial-Abundance (HMA), while sponges with low microbial abundance are called Low-Microbial-Abundance (LMA). The microbes that symbiotically interact with sponges, known as secondary metabolite producers, are members of the Actinobacteria group.
The increasing public demand for seafood and the degradation of natural habitats have led to the threat of widespread infections in intensively farmed animals, which could result in significant losses in fisheries production. Data from the Central Statistics Agency (BPS) shows that the potential fish resources in Indonesian waters reach 67 million tons per year. This figure includes capture fisheries at 9.3 million tons per year and aquaculture at 56.8 million tons per year. The Food and Agriculture Organization (FAO) predicts that the world population will grow by 30% by 2050, followed by a 70% increase in global protein demand. The application of biotechnology to significantly advance the commercial aquaculture industry has become a primary focus in efforts to increase productivity, control disease and health through vaccination, manage sustainably formulated feed nutrition, and address environmental challenges facing fisheries resources.
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