Sponges are marine invertebrates that possess more than 20 categories of bioactive compounds, including antibiotics, antivirals, anti-inflammatories, anticancer, antileukemic, insecticidal, antihelminthic, and cytotoxins, making them attractive for development. Nutritionally, sponges are more suitable as microbial niches than nutrient-poor seawater. The interaction between bacteria and sponges is called mutualistic symbiosis, producing bioactive compounds. Sponges with high microbial abundance are called High-Microbial-Abundance (HMA), while sponges with low microbial abundance are called Low-Microbial-Abundance (LMA). The microbes that symbiotically interact with sponges, known as secondary metabolite producers, are members of the Actinobacteria group.
Indonesia has rich marine biodiversity and potential for development. Abundant marine resources are not only a food source but can also be developed into medicinal ingredients. Marine invertebrates are the marine organisms that produce the largest number of bioactive compounds compared to marine vertebrates. This is because marine invertebrates have more limited physical movement than marine vertebrates, resulting in a greater response to bioactive compound production. Marine invertebrates with biological activity include sponges, ascidians, mollusks, and bryozoans. In the past decade, the world's attention in medicine has begun to turn to marine organisms as a potential source of these compounds. The need for new antibiotics is high, especially those that are effective in inhibiting resistant pathogenic bacteria. Therefore, information about active antibacterial compounds in the health sector is crucial in combating diseases caused by bacteria. Infectious diseases are diseases cau...